Detalhe da pesquisa
1.
Molecular basis for control of antibiotic production by a bacterial hormone.
Nature
; 590(7846): 463-467, 2021 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-33536618
2.
Metagenomic domain substitution for the high-throughput modification of nonribosomal peptides.
Nat Chem Biol
; 20(2): 251-260, 2024 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-37996631
3.
Parallelized gene cluster editing illuminates mechanisms of epoxyketone proteasome inhibitor biosynthesis.
Nucleic Acids Res
; 51(3): 1488-1499, 2023 02 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-36718812
4.
Antibiotic Skeletal Diversification via Differential Enoylreductase Recruitment and Module Iteration in trans-Acyltransferase Polyketide Synthases.
J Am Chem Soc
; 146(9): 6114-6124, 2024 Mar 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-38389455
5.
Diene incorporation by a dehydratase domain variant in modular polyketide synthases.
Nat Chem Biol
; 18(12): 1410-1416, 2022 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-36109649
6.
Expanding the Substrate Scope of Nitrating Cytochrome P450 TxtE by Active Site Engineering of a Reductase Fusion.
Chembiochem
; 22(13): 2262-2265, 2021 07 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-33851500
7.
Docking domain-mediated subunit interactions in natural product megasynth(et)ases.
J Ind Microbiol Biotechnol
; 48(3-4)2021 Jun 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-33640957
8.
Catalytic Mechanism of Aromatic Nitration by Cytochrome P450 TxtE: Involvement of a Ferric-Peroxynitrite Intermediate.
J Am Chem Soc
; 142(37): 15764-15779, 2020 09 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-32811149
9.
Mechanism of intersubunit ketosynthase-dehydratase interaction in polyketide synthases.
Nat Chem Biol
; 14(3): 270-275, 2018 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-29309054
10.
Heterologous reconstitution of the biosynthesis pathway for 4-demethyl-premithramycinone, the aglycon of antitumor polyketide mithramycin.
Microb Cell Fact
; 19(1): 111, 2020 May 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-32448325
11.
Genomics-Driven Discovery of a Novel Glutarimide Antibiotic from Burkholderia gladioli Reveals an Unusual Polyketide Synthase Chain Release Mechanism.
Angew Chem Int Ed Engl
; 59(51): 23145-23153, 2020 12 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-32918852
12.
Discovery and Biosynthesis of Bolagladins: Unusual Lipodepsipeptides from Burkholderia gladioli Clinical Isolates*.
Angew Chem Int Ed Engl
; 59(48): 21553-21561, 2020 11 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-32780452
13.
Binding of Distinct Substrate Conformations Enables Hydroxylation of Remote Sites in Thaxtomin D by Cytochrome P450 TxtC.
J Am Chem Soc
; 141(1): 216-222, 2019 01 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-30516965
14.
Protein-protein interactions in trans-AT polyketide synthases.
Nat Prod Rep
; 35(10): 1097-1109, 2018 10 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-30280735
15.
Rieske non-heme iron-dependent oxygenases catalyse diverse reactions in natural product biosynthesis.
Nat Prod Rep
; 35(7): 622-632, 2018 07 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-29651484
16.
Structure, Chemical Synthesis, and Biosynthesis of Prodiginine Natural Products.
Chem Rev
; 116(14): 7818-53, 2016 07 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-27314508
17.
In Vitro Biosynthetic Studies of Bottromycin Expand the Enzymatic Capabilities of the YcaO Superfamily.
J Am Chem Soc
; 139(50): 18154-18157, 2017 12 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-29200283
18.
Discovery and Biosynthesis of Gladiolin: A Burkholderia gladioli Antibiotic with Promising Activity against Mycobacterium tuberculosis.
J Am Chem Soc
; 139(23): 7974-7981, 2017 06 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-28528545
19.
A Flavin-Dependent Decarboxylase-Dehydrogenase-Monooxygenase Assembles the Warhead of α,ß-Epoxyketone Proteasome Inhibitors.
J Am Chem Soc
; 138(13): 4342-5, 2016 Apr 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-26999044
20.
Discovery of Unusual Biaryl Polyketides by Activation of a Silent Streptomyces venezuelae Biosynthetic Gene Cluster.
Chembiochem
; 17(22): 2189-2198, 2016 Nov 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-27605017